Richard and Loan Hill Department of Bioengineering

Bioengineering is a field of engineering science that develops and applies quantitative analysis and design to living systems and hybrid systems containing living components. Biological systems are interesting, efficient and successful, but also highly complex; they are dynamic, nonlinear, self-repairing, and yet programmed to terminate. The classic engineering approach of measure-and-model must be carefully recast to deal with the complex nature of living systems, requiring bioengineers to balance analytical rigor with innovation.

Bioengineers are uniquely qualified to work at the interface between living and nonliving systems, enhancing our ability to analyze, repair or replace physiological substances or processes as needed in healthcare and research applications. Potential applications include creating engineered bone replacements, developing new tools for noninvasive imaging or diagnostics, and the design of molecules as new therapeutic drugs. Training in bioengineering prepares students for graduate school or industry, and is an excellent preparation for professional programs (medicine, dentistry, nursing, pharmacy and patent law). Exciting career opportunities exist for bioengineers at the BS level in the medical device, pharmaceutical and biotechnology industries, in hospitals, and in federal laboratories and agencies.

The department faculty routinely includes undergraduate students in world-class bioengineering research programs, and maintains strong interactions with faculty in the Colleges of Medicine, Dentistry, and Pharmacy, and the Department of Biological Sciences and other engineering disciplines. The undergraduate curriculum includes rigorous training in bioengineering fundamentals, including medical product development, complimented by significant course work in physiology, mathematics and chemistry. Each student must complete a program of required core courses and select an individualized course track in one specialized area (Neural Engineering, Cell and Tissue Engineering, or Bioinformatics) best suited to the student’s interests. The department offers several elective courses to help prepare students for a variety of career paths, including launching start-up companies or careers in industry or consulting. Internships, clinical immersion programs, design competitions, and several active professional societies are among the extracurricular activities available to students.

The department Mission Statement and the Educational Objectives for the Bachelor of Science in Bioengineering can be found at the departmental website www.bioe.uic.edu.

Accreditation

The Richard and Loan Hill Department of Bioengineering offers a program of study leading to the degree of Bachelor of Science in Bioengineering that is accredited by the Accreditation Board for Engineering and Technology www.abet.org.

Courses

BIOE 101. Introduction to Bioengineering. 3 hours.

Principles, practice, and the role of bioengineers in science, engineering, and commercialization of medical products. Professional ethics, career paths, introduction to graphical design tools and instrumentation. Course Information: Previously listed as BIOE 200.

BIOE 102. Bioengineering Freshman Seminar. 1 hour.

Exposure to bioengineering research through attendance of graduate student seminars followed by faculty-mediated discussion. Writing seminar summaries, graduate student shadowing, articulating long-term goals, and planning an academic trajectory. Course Information: Satisfactory/Unsatisfactory grading only. Restricted to first year bioengineering students (freshmen or transfer students).

BIOE 205. Bioengineering Thermodynamics. 3 hours.

Introduction to equilibrium and non-equilibrium thermodynamics, with emphasis on non-equilibrium (living) systems. Applications include thermodynamics of living cells and the lung, molecular energy exchange, and energy exchange in exercise. Course Information: Prerequisite(s): PHYS 141.

BIOE 240. Modeling Physiological Data and Systems. 3 hours.

A lecture/discussion course introducing the use of mathematical models and statistics to describe, interpret and analyze physiological data and systems. Course Information: Prerequisite(s): BIOS 100; and MATH 180; and CS 109. Open only to freshmen and sophomores.

BIOE 250. Clinical Problems in Bioengineering. 3 hours.

Examination of three current problems in bioengineering. Student teams work with a faculty facilitator toward each solution. Problem identification, strategic planning, brainstorming, information gathering, and reporting. Course Information: Prerequisite(s): Credit or concurrent registration in BIOE 101 and credit or concurrent registration in BIOE 102.

BIOE 310. Biological Systems Analysis. 3 hours.

System dynamics and frequency-domain analysis in bioengineering systems. Topics include population models, predator-prey models, metabolic networks, biological oscillation, dynamics of infectious diseases. Course Information: No credit given if the student has credit in ECE 310 or ME 312. Prerequisite(s): MATH 220 and MATH 310 and BIOE 240.

BIOE 325. Biotransport. 3 hours.

Transport phenomena in biomedical engineering and living systems, specifically processes vital to the design of medical devices for artificial clinical intervention. Topics include circulatory system dynamics and modeling of physiological systems. Course Information: Prerequisite(s): MATH 220 and BIOS 100 and BIOE 205.

BIOE 339. Biostatistics I. 3 hours.

Statistical treatment of data and model estimation treated in a framework of biological experiments, and attributes of data generated from such experiments. Experimental design is included. Course Information: Extensive computer use required. Prerequisite(s): MATH 210; and CS 109. Recommended Background: Prior knowledge of Excel.

BIOE 396. Senior Design I. 3 hours.

Design considerations for biomedical devices emphasizing traditional engineering design concepts. Course Information: Prerequisite(s): Credit or concurrent registration in BIOE 339.

BIOE 397. Senior Design II. 3 hours.

Application of principles of engineering and engineering design methodology to the solution of a large scale biomedical engineering design problem. Course Information: Prerequisite(s): BIOE 396.

BIOE 398. Undergraduate Research. 1-5 hours.

Research under the close supervision of a faculty member. Course Information: May be repeated. Students may register in more than one section per term. Prerequisite(s): Consent of the instructor.

BIOE 399. Professional Development for Bioengineers. 0 hours.

Career options, career planning, and job search skills relevant to bioengineers. Formal and informal networking, on-line resources, resume and portfolio preparation, interview skills. Special issues relevant to international students. Course Information: Satisfactory/Unsatisfactory grading only. Prerequisite(s): Open only to juniors; or consent of the instructor.

BIOE 402. Medical Technology Assessment. 2 or 3 hours.

Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

BIOE 403. Quality Assurance for Medical Products. 2 or 3 hours.

Requirements for current good manufacturing practices and quality assurance in the design and manufacture of medical devices. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): BIOE 250; and junior standing or above; or consent of the instructor.

BIOE 405. Atomic and Molecular Nanotechnology. 3 or 4 hours.

Nanoscale structures and phenomena. Simulation methods for nano systems, and molecular assemblies. Molecular building blocks, scanning probe and atomic force microscopy, quantum mechanical phenomena. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Senior standing or above. Recommended background: Engineering or physical science major.

BIOE 406. Regulation and Manufacturing Practices in Medical Technology. 2 or 3 hours.

Bioentrepreneur course. Product requirement definition, FDA, quality system regulation, community Europe, medical device directive, role of management, United States pharmacopoeia, toxicity testing, hazard analysis, risk assessment, import/export. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

BIOE 407. Pattern Recognition I. 3 or 4 hours.

The design of automated systems for detection, recognition, classification and diagnosis. Parametric and nonparametric decision-making techniques. Applications in computerized medical and industrial image and waveform analysis. Course Information: Same as ECE 407. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): MATH 220.

BIOE 408. Medical Product Development. 2 or 3 hours.

Bioentrepreneur course. Major stages of medical product development (investigative, feasibility, development, commercialization, maturation and growth), regulatory issues, product performance, failure mode and effect analysis, hazard analysis. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

BIOE 410. FDA and ISO Requirements for the Development and Manufacturing of Medical Devices. 3 or 4 hours.

FDA Performance Standard for General Medical Devices for manufacturing and development engineers. Product requirement definition, design control, hazard analysis, failure mode and effect analysis, regulatory submission, product tests, ISO 9001. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100 and BIOE 250. Recommended background: Junior standing or above.

BIOE 415. Biomechanics. 3 or 4 hours.

Continuum mechanics of cells, tissues and organs. Statics and force balances; stress, strain and constitutive relations; equilibrium, universal solutions and inflation; finite deformation; nonlinear problems; finite element methods. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310.

BIOE 420. Introduction to Field and Waves in Biological Tissues. 3 or 4 hours.

Principles of electromagnetic and ultrasonic interaction with biological systems; characterization of biological materials; diagnostic and therapeutic uses; and techniques of dosimetry and measurement. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): ECE 310.

BIOE 421. Biomedical Imaging. 3 or 4 hours.

Introduction to engineering and scientific principles associated with X-ray, magnetic resonance, ultrasound, computed tomographic and nuclear imaging. Course Information: 3 undergraduate hours. 4 graduate hours. Extensive computer use required. Prerequisite(s): MATH 210 and PHYS 142; and BIOS 443 or BIOS 483.

BIOE 422. Magnetic Resonance Imaging. 3 or 4 hours.

Fundamental priciples of magnetic resonance imaging (MRI) from a signal processing perspective. Focus on image acquisition, formation, and analysis. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310 or ECE 310; and junior standing or above; or consent of the instructor.

BIOE 423. Biomedical Imaging Laboratory. 2 hours.

Acquisition and processing of biomedical imaging data. Relaxation time-based magnetic resonance imaging, motion sensitive magnetic resonance imaging, computed tomography, ultrasound and optical imaging. Course Information: Prerequisite(s): Credit or concurrent registration in BIOE 421.

BIOE 430. Bioinstrumentation and Measurements I. 3 or 4 hours.

Theory and application of instrumentation used for physiological and medical measurements. Characteristics of physiological variables, signal conditioning devices and transducers. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100 and ECE 115 or ECE 210; and BIOE 310.

BIOE 431. Bioinstrumentation and Measurement Laboratory. 2 hours.

Practical experience in the use of biomedical instrumentation for physiological measurements. Course Information: Prerequisite(s): Credit or concurrent registration in BIOE 430.

BIOE 432. Bioinstrumentation and Measurements II. 3 or 4 hours.

Principles of bioinstrumentation for the assessment of physiological function and therapeutic intervention. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 430.

BIOE 433. Bioinstrumentation and Measurements II Laboratory. 1 hour.

Laboratory experiments using instruments to assess physiological function. Course Information: Prerequisite(s): Credit or concurrent registration in BIOE 432.

BIOE 439. Biostatistics II. 4 hours.

Statistical treatment of data, model estimation, and inference are treated in a framework of biological experiments and attributes of data generated from such experiments. Course Information: Credit is not given for BIOE 439 if the student has credit for BSTT 400. Extensive computer use required. Prerequisite(s): MATH 210 and CS 109 and BIOE 339; and consent of the instructor. Recommended background: Knowledge of MATLab.

BIOE 440. Biological Signal Analysis. 3 or 4 hours.

Analysis of signals of biological origin. Transient signals. Stability analysis. Control. Probabilities, stochastic processes. Medical applications. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Senior or graduate standing; and MATH 210 and MATH 310.

BIOE 450. Molecular Biophysics of the Cell. 4 hours.

Introduction to force, time energies at nanometer scales; Boltzmann distribution; hydrodynamic drag; Brownian motions; DNA, RNA protein structure and function; sedimentation; chemical kinetics; general aspects of flexible polymers. Course Information: Same as PHYS 450. Prerequisite(s): PHYS 245 or the equivalent; or approval of the department.

BIOE 452. Biocontrol. 3 or 4 hours.

Considers the unique characteristics of physiological systems using the framework of linear systems and control theory. Static and dynamic operating characteristics, stability, and the relationship of pathology to control function. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310.

BIOE 455. Introduction to Cell and Tissue Engineering. 3 or 4 hours.

Foundation of cell and tissue engineering covering cell technology, construct technology, and cell-substrate interactions. Emphasis in emerging trends and technologies in tissue engineering. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 260; and BIOS 443 or BIOS 452.

BIOE 456. Cell and Tissue Engineering Laboratory. 2 hours.

Includes polymer scaffold fabrication, microstamping biomolecules, cellular adhesion and proliferation assays, and immo/fluorescent tagging. Course Information: Prerequisite(s): Credit or concurrent registration in BIOE 455; or consent of the instructor.

BIOE 460. Materials in Bioengineering. 3 or 4 hours.

Analysis and design considerations of problems associated with prostheses and other implanted biomedical devices. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): CME 260; and BIOS 220 or BIOS 240 or BIOS 286 or CHEM 234.

BIOE 465. Metabolic Engineering. 3 or 4 hours.

Quantitative descriptions of biochemical networks; modeling, control, and design of metabolic pathways to achieve industrial and medical goals. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310 or ECE 310 or ME 312; or consent of the instructor.

BIOE 470. Bio-Optics. 3 or 4 hours.

Physical principles and instrumentation relevant to the use of light in biomedical research. Several current and developing clinical applications are explored. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): PHYS 142.

BIOE 472. Models of the Nervous System. 3 or 4 hours.

Mathematical models of neural excitation and nerve conduction, stochastic models and simululation of neuronal activity, models of neuron pools and information processing, models of specific neural networks. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 310; and credit or concurrent registration in BIOS 484.

BIOE 475. Neural Engineering I: Introduction to Hybrid Neural Systems. 3 or 4 hours.

Modeling and design of functional neural interfaces for in vivo and in vitro applications, electrodes and molecular coatings, neural prostheses and biopotential control of robotics. Course Information: Same as BIOS 475. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOE 472; or consent of the instructor.

BIOE 476. Neural Engineering I Laboratory. 2 hours.

Hands-on experience with computational and experimental models of engineered neural systems, with emphasis on neuroprostheses and biosensors. Course Information: Animals used in instruction. Prerequisite(s): Credit or concurrent registration in BIOE 475.

BIOE 480. Introduction to Bioinformatics. 3 or 4 hours.

Computational analysis of genomic sequences and other high throughput data. Sequence alignment, dynamic programming, database search, protein motifs, cDNA expression array, and structural bioinformatics. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 100 and CS 109.

BIOE 481. Bioinformatics Laboratory. 2 hours.

How to use bioinformatics tools, including sequence alignment methods such as Blast, Fasta, and Pfam, as well as structural bioinformatics tools, such as Rasmol and CastP. Course Information: Extensive computer use required. Prerequisite(s): Credit or concurrent registration in BIOE 480; and senior standing or above; and consent of the instructor.

BIOE 482. Introduction to Optimization Methods in Bioinformatics. 3 or 4 hours.

The objectives are to provide the students with a basis for understanding principles of the optimization methods and an insight on how these methods are used in bioinformatics. Course Information: 3 undergraduate hours. 4 graduate hours. Extensive computer use required. Prerequisite(s): BIOS 100 and CS 201 and MATH 310.

BIOE 483. Molecular Modeling in Bioinformatics. 3 or 4 hours.

Basic structural and dynamics tools in protein structure prediction, structure comparison, function prediction, Monte Carlo and molecular dynamics simulations. Course Information: 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Grade of B or better in BIOE 480.

BIOE 494. Special Topics in Bioengineering. 1-4 hours.

Special topics to be arranged. Course Information: May be repeated. Students may register in more than one section per term. Prerequisite(s): Consent of the instructor.