Molecular and gene therapy, using small molecules including antisense, aptamers, and proteins. Structure-based drug design. Structural bioinformatics and drug discovery program. High-throughput screening. Combinatorial chemistry technology. Course Information: Same as CHEM 458. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): BIOS 352 or CHEM 352; or Credit or concurrent registration in BIOS 452 or Credit or concurrent registration in CHEM 452; or consent of the instructor.